Psychopharmacology (Berl). 2005 Aug 13;:1-5 Epub ahead of print Links
Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia.
Dakhale GN, Khanzode SD, Khanzode SS, Saoji A.
Department of Pharmacology, Government Medical College, Nagpur, India.
RATIONALE: Several investigators implicated role of free radical-mediated pathology in schizophrenia. No study has ever examined the effect of vitamin C with atypical antipsychotics in the treatment of schizophrenia. OBJECTIVE: The aim of this study was to examine the effect of oral vitamin C with atypical antipsychotics on serum malondialdehyde (MDA), plasma ascorbic acid levels, and brief psychiatric rating scale (BPRS) score in schizophrenic patients. METHOD: Forty schizophrenic patients participated in a prospective, double-blind, placebo-controlled, noncrossover, 8-week study. The patients with schizophrenia were divided randomly into placebo and vitamin C group of 20 each. Serum MDA and plasma ascorbic acid were estimated by methods of Nischal and Aye, respectively. RESULT: Increased serum MDA and decreased plasma ascorbic acid levels were found in schizophrenic patients. These levels were reversed significantly after treatment with vitamin C along with atypical antipsychotics compared to placebo with atypical antipsychotics. BPRS change scores at 8 weeks improved statistically significant with vitamin C as compared to placebo. CONCLUSION: Oral supplementation of vitamin C with atypical antipsychotic reverses ascorbic acid levels, reduces oxidative stress, and improves BPRS score, hence both the drugs in combination can be used in the treatment of schizophrenia.
PMID: 16133138 PubMed - as supplied by publisher
--------------------------------------------------------------------------------
Who loves ya. Tom
Jesus Was A Vegetarian!
Man Is A Herbivore!
DEAD PEOPLE WALKING