Iron induced increase in adjuvant arthritis synovitis 2636

What .. part .. OF .. "giving iron supplements to a mammal WITH .. arthritis .. is a BAD .. thing .." .. don't you .. understand .. ?

Heh .. heh ..

Seems if you give iron supplements to animals .. OR .. children with arthritis .. it .. HURTS .. them ..

But .. it seems .. the FACT .. it HURTS .. animals AND or children .. makes NO .. nevermind to .. YOU ..

I am just happy that .. you don't realize .. that when it hurts animals and children .. it very likely ALSO hurts .. you ..

That means since you didn't ."go to the wall for the kids .. " .. when I first posted the supplements hurting KIDS .. study .. means by NOT .. advocating FOR .. the .. kids .. you .. effectively cut your .. OWN .. throat ..

Heh .. heh ..

Looks .. good .. on .. ya ..

hasten joint deterioration By Diana Swift WWASHINGTON, D.C. - The iron supplements that many arthritic children take to combat concomitant anemia may be hastening the deterioration of their joints, Houston researchers say. Led by biologist Roman Shypailo of the Children's Nutrition Research Centre at Baylor College of Medicine, a Texas team looked at eight children being treated for juvenile rheumatoid arthritis. The patients, aged five to 15 years, received an intravenous radioactive tracer dose of iron (0.03 microsievert). Iron activity in affected joints was monitored on a position-energy-sensitive gamma counter, while a second machine monitored whole-body iron retention. Iron deposition was measured two hours post-infusion and again at days seven, 14, 28 and 56. Anemic "We found that iron excessively accumulates in arthritic joints and probably contributes to the chronic damage," said Shypailo. "That puts you between a rock and a hard place because many of these arthritic kids are anemic and need iron supplements, which may worsen the disease." The study found a high level of agreement between the joint data and the whole-body data, with a greater than 90% retention rate of the infused iron both in joints and systemically. Furthermore, six of eight patients showed increased uptake at the affected joints: 165% over the first 30 days compared with initial uptake at two hours. The next step, he says, is to see if there is excessive deposition of dietary iron in arthritic joints.

IRON DEPOSITION IN THE JOINTS OF CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS

Author(s): SHYPAILO ROMAN J ELLIS KENNETH J PEREZ MARIA ABRAMS STEVEN A

Interpretive Summary: We wanted to develop an accurate and noninvasive way of determining the amount of iron deposited in the joints of patients with juvenile rheumatoid arthritis. Children with JRA often develop excess iron in their joints, so doctors need a way of monitoring the iron level, particularly when prescribing iron supplements for the common problem of anemia. However, the only method currently available is to take a biopsy. We adapted a machine called a gamma counter to measure the iron in eight patients' joints after giving them an iron isotope by vein. Then we compared the results with the total amount of iron in their bodies, measured by a whole-body counter. We found that we had developed an accurate new way of measuring iron in these patients' joints. We also found that six of the eight subjects had excess uptake of the iron isotope in their joints. That provided a signal that a preponderance of JRA patients are prone to have this problem, and clinicians should take special care to monitor them for it. Moreover, this is the first time a noninvasive way of performing this measurement has been available.

Keywords: energy reproduction growth body composition women infants children water potbuttium bioelectrical impedance conductance bromide space lactating iron adipose tissue lipid motabolism beta-adrenergic receptor cell culture neutron activation nitrogen carbon calcium sodium chlorine phosphorus hormonal changes differentiation adipocyte hnrim021125

Contact: USDA-ARS CHILDREN'S NUTR 1100 BATES ST. HOUSTON TX 77030 FAX: (713)798-7130

TEKTRAN United States Department of Agriculture Agricultural Research Service

Updated: 1999-01-16

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